ZEJULA (niraparib)

TherapyGSK

Zejula (niraparib) is an oral PARP inhibitor that blocks DNA repair in cancer cells, used as maintenance therapy for advanced or recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer.

Approvals
1
Indications
1
Biomarkers
1
Mapped tests
1

Where this therapy is approved with a companion diagnostic

Each row represents a defined combination of indication, biomarker criteria, and ZEJULA. Select a testing pathway to see the eligible companion diagnostic tests.

Indication-specific approvals

Approvals where ZEJULA is tied to a specific indication and biomarker definition.

IndicationBiomarker criteriaNotes
Ovarian Cancer
Solid Tumor · Ovary
HRD
  • Deleterious or suspected deleterious germline or somatic mutations in BRCA1 and BRCA2 genes and/or positive Genomic Instability Score
View testing pathway →
Tumor-agnostic approvals

Approvals defined at the solid tumor level where biomarker criteria determine eligibility for ZEJULA.

No tumor-agnostic companion diagnostic approvals are currently mapped for this therapy.

Tests used in these approvals

These assays are identified in FDA labeling or sponsor materials as companion diagnostics or acceptable tests when considering ZEJULA for eligible patients.

Test
Myriad myChoice CDx
Myriad Genetics
Method
NGS
Specimen
Tissue (FFPE)
This view is scoped to ZEJULA (niraparib). You can also see how it compares with other therapies and indications on the main Know Your Companions™ map.
ZEJULA (niraparib) | CDxTests.com | CDx Tests