LEPR
LEPR encodes the leptin receptor and is involved in energy balance regulation. Pathogenic variants are relevant in rare obesity disorders and therapeutic eligibility.
Where this biomarker is used
Each approval combines this biomarker with a specific indication and therapy. Select a therapy in the tables below to open its FDA-defined testing pathway.
Approvals where LEPR is defined directly in the indication labeling.
| Indication | Biomarker criteria | Therapies |
|---|---|---|
Obesity Other · Metabolic |
|
Approvals defined at the solid tumor level where LEPR is part of the eligibility criteria.
No tumor-agnostic approvals are currently mapped for this biomarker.
Tests that measure this biomarker
These assays report LEPR as part of their validated menu. In many cases they are identified in FDA labeling as acceptable companion diagnostics for specific approvals.
Reports LEPR as part of its biomarker panel.