VECTIBIX (panitumumab)

TherapyAmgen

VECTIBIX (panitumumab) from Amgen is an EGFR-directed antibody used in RAS wild-type colorectal cancer.

Approvals

Indications

Biomarkers

Mapped tests

Where this therapy is approved with a companion diagnostic

Each row represents a defined combination of indication, biomarker criteria, and VECTIBIX. Select a testing pathway to see the eligible companion diagnostic tests.

Indication-specific approvals

Approvals where VECTIBIX is tied to a specific indication and biomarker definition.

Indication	Biomarker criteria	Notes
Colorectal Cancer (CRC) Solid Tumor · Colorectal	KRAS Mutations in codons 12 and 13 of KRAS gene		View testing pathway →
Colorectal Cancer (CRC) Solid Tumor · Colorectal	EGFR (HER1) protein expression		View testing pathway →

Tumor-agnostic approvals

Approvals defined at the solid tumor level where biomarker criteria determine eligibility for VECTIBIX.

No tumor-agnostic companion diagnostic approvals are currently mapped for this therapy.

Tests used in these approvals

These assays are identified in FDA labeling or sponsor materials as companion diagnostics or acceptable tests when considering VECTIBIX for eligible patients.

Test

cobas KRAS Mutation Test

Roche Molecular Systems, Inc. (Roche Diagnostics)

Method

PCR

Specimen

Tissue (FFPE)

1 approvalView test profile →

Test

CRCDx RAS Mutation Detection Assay Kit

EntroGen, Inc.

Method

PCR

Specimen

Tissue (FFPE)

1 approvalView test profile →

Test

Dako EGFR pharmDx Kit

Dako North America, Inc. (Agilent Technologies, Inc.)

Method

IHC

Specimen

Tissue (FFPE)

1 approvalView test profile →

Test

FoundationOne CDx

Foundation Medicine, Inc.

Method

NGS

Specimen

Tissue (FFPE)

1 approvalView test profile →

Test

MI Cancer Seek (MCS)

Caris Life Sciences

Method

NGS

Specimen

Tissue (FFPE)

1 approvalView test profile →

Test

ONCO/Reveal Dx Lung & Colon Cancer Assay (O/RDx-LCCA)

Pillar Biosciences, Inc.

Method

NGS

Specimen

Tissue (FFPE)

1 approvalView test profile →

Test

Praxis Extended RAS Panel

Illumina, Inc.

1 approvalView test profile →

Test

therascreen KRAS RGQ PCR Kit

Qiagen Manchester, Ltd. (Qiagen)

Method

PCR

Specimen

Tissue (FFPE)

1 approvalView test profile →

Test

xT CDx

Tempus

Method

NGS

Specimen

Tissue (FFPE)

1 approvalView test profile →

This view is scoped to VECTIBIX (panitumumab). You can also see how it compares with other therapies and indications on the main Know Your Companions™ map.